We are seeking an experienced Bioinformatics Software Engineer specializing in C++ to join our Instrument Analysis team at PacBio (NASDAQ PACB). In this role, you will develop high-performance on-instrument software tools and algorithms that further our mission to advance scientific understanding through cutting-edge technologies. This position demands deep technical expertise in modern C++ development, along with specialized knowledge of bioinformatics algorithms and statistical modeling.

Responsibilities

Design and implement efficient bioinformatics algorithms for sequence analysis in modern C++, meeting performance-critical requirements.
Profile and optimize code to enhance memory efficiency and computational speed.
Develop clean, well-documented APIs and libraries suitable for integration into broader software ecosystems.
Collaborate with team members, sharing insights and best practices, and fostering a culture of continuous improvement.
Maintain comprehensive and clear documentation covering software design, implementation, and optimization strategies.

Required Qualifications

Master's or Ph.D. in Bioinformatics, Computational Biology, Computer Science, or a related field.
5+ years of professional C++ development experience using modern standards.
Expert-level understanding of core bioinformatics concepts, particularly in sequence analysis.
Proven experience developing complex algorithms with careful consideration of time and space complexity.
Proficiency with version control (Git), automated testing, continuous integration, and code review processes.
Experience with memory management, multi-threading, and system-level optimization.
Familiarity with common bioinformatics file formats (FASTA, FASTQ, SAM/BAM/CRAM, VCF).
Demonstrated ability to debug complex software systems and identify performance bottlenecks.
Excellent interpersonal, written, and verbal communication skills.

Preferred Experience

Knowledge of statistical methods and machine learning techniques in bioinformatics.
Familiarity with scientific visualization libraries and tools.
Contributions to open-source bioinformatics projects or tools.

This role is not eligible for visa sponsorship.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

_Salary Range

_$170,400.00 - $293,900.00

To all Staffing and Recruiting Agencies Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or careers@pacificbiosciences.com for assistance.

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About PacBio

👥501-1000

📍Menlo Park, CA

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How does PacBio work?

At PacBio, we’re devoted to empowering you. Pioneering the future through biology takes vision. You have to look beyond the status quo to what’s possible.We know your vision can reveal the full potential of the genome, advance human health and the health of our planet. And that is why your vision and pursuit are at the very center of what our company does — our product design, our customer support model, our partnerships, and even our identity.We create the world’s most advanced sequencing systems to provide you the most complete and accurate view of genomes, transcriptomes, and epigenomes. Our founders invented a new way to study the synthesis and regulation of DNA, RNA, and proteins. Driven by a desire to advance human health, we’re harnessing advances in biochemistry, optics, nanofabrication, and more.We are passionate about developing products that empower scientists to explore the full spectrum of genetic variation in any organism — from unraveling the mystery of rare diseases to improving the world’s food supply. With world-class service and support, we keep your research progressing so you can focus on finding answers.