Senior Security Engineer

Senior Security Engineer

United States

Company-Wide – Open Roles /

Full-time /

Remote

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Sequencing.com is seeking a highly skilled and self-directed Senior Security Engineer to take the lead on proactively identifying and closing security gaps across our infrastructure, applications, and data pipelines. This role requires deep offensive security expertise, with a strong emphasis on penetration testing, vulnerability discovery, and threat modeling across both cloud and on-prem environments.

You will work across engineering, DevOps, and bioinformatics teams, serving as a hands-on offensive security lead and a strategic partner to our architects. You’ll plan and execute pen tests - internally or with vendors - across critical areas of the business, while also contributing to long-term security architecture and certification readiness (e.g., HIPAA, SOC 2). This is a senior IC role with broad scope, deep technical expectations, and the opportunity to shape our security posture from the ground up.

What You’ll Do

• Lead the planning and execution of offensive security testing across web applications, APIs, infrastructure, and networks.

• Conduct manual and automated penetration testing and vulnerability assessments; document findings and guide remediation.

• Work with DevOps, architects, and engineering leads to embed security throughout CI/CD, infrastructure, and data workflows.

• Plan and run regular security audits and threat modeling sessions; coordinate with third-party firms when needed.

• Proactively identify and resolve security gaps in complex, custom systems spanning cloud and on-prem environments.

• Design, implement, and maintain security controls, tooling, and detection capabilities that scale with the business.

• Develop roadmaps for security certifications (e.g., HIPAA, SOC 2, ISO 27001) and lead technical implementation efforts.

• Manage incident response procedures, conduct postmortems, and implement long-term prevention measures.

• Create and maintain high-quality documentation for security processes, infrastructure risks, and compliance status.

• Stay current on threat landscapes, tools, and best practices relevant to ecommerce, health data, and hybrid infrastructures.

What We’re Looking For

• 5+ years of experience in security engineering, DevSecOps, or infrastructure security roles.

• Deep technical understanding of cloud security (AWS, OCI) and on-prem environments.

• Experience with container security, CI/CD hardening, key/secret management, and secure software development practices.

• Hands-on experience with security audits and penetration testing, whether conducted in-house or via third parties.

• Proven ability to create and execute security certification roadmaps (SOC 2, HIPAA, ISO 27001, etc.).

• Strong documentation practices; able to write clear runbooks, security policies, and architecture diagrams.

• Comfortable working in highly customized, complex environments.

• Strong understanding of Linux, networking, authentication, and monitoring.

• Ability to operate autonomously while collaborating across multiple disciplines and technical stacks.

• Experience using AI or ML tools to enhance security initiatives, such as accelerating threat detection, automating security monitoring, improving anomaly detection, or integrating AI-driven platforms into incident response workflows.

Nice to Have

• Experience with security in regulated environments such as healthcare, biotech, or genomics (e.g., HIPAA, GINA, 21 CFR Part 11), ideally within rapidly scaling consumer health or healthtech platforms handling sensitive user data.

• Familiarity with securing ecommerce platforms, including fraud prevention and secure checkout workflows.

• Hands-on experience with penetration testing tools (e.g., Burp Suite, Metasploit) or managing third-party pen test vendors.

• Security certifications such as CISSP, OSCP, or AWS Certified Security – Specialty.

About Sequencing

Sequencing is powering the future of personalized health. We are the platform that transforms a person’s genome into a lifelong source of straightforward, actionable insights - for individuals, families, and healthcare professionals. By providing the application layer to your DNA, we turn complex genetic data into recurring value throughout every stage of life.

Our unique, clinical-grade Whole Genome Sequencing unlocks the most complete view of your DNA, screening for almost all known health conditions, traits, and medication responses - and translating that information into clear, actionable steps for managing health risks, optimizing wellness, and extending longevity.

As whole genome sequencing becomes a standard part of life, Sequencing is already the trusted platform where people safely store their DNA data - and will become the lifelong home for every genome on Earth. We’re a fully remote, global team of innovators, scientists, and builders, united by a mission to make genomics accessible, actionable, and life-changing for everyone. Proudly named GenomeWeb’s Best Place to Work in 2024, Sequencing is venture-backed and scaling rapidly to meet surging demand in the fast-growing personal genomics market.

If you’re excited to help redefine how the world thinks about health, join us in building the platform that brings every genome to life.

Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

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$115,000 - $145,000 a year

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

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