Staff Software Engineer, Infrastructure

Why join Freenome?

Freenome is a high-growth biotech company developing tests to detect cancer using a standard blood draw. To do this, Freenome uses a multiomics platform that combines tumor and non-tumor signals with machine learning to find cancer in its earliest, most-treatable stages.

Cancer is relentless. This is why Freenome is building the clinical, economic, and operational evidence to drive cancer screening and save lives. Our first screening test is for colorectal cancer (CRC) and advanced adenomas, and it’s just the beginning.

Founded in 2014, Freenome has ~400 employees and continues to grow to match the scope of our ambitions to provide access to better screening and earlier cancer detection.

At Freenome, we aim to impact patients by empowering everyone to prevent, detect, and treat their disease. This, together with our high-performing culture of respect and cross-collaboration, is what motivates us to make every day count.

Become a Freenomer

Do you have what it takes to be a Freenomer? A “Freenomer” is a determined, mission-driven, results-oriented employee fueled by the opportunity to change the landscape of cancer and make a positive impact on patients’ lives. Freenomers bring their diverse experience, expertise, and personal perspective to solve problems and push to achieve what’s possible, one breakthrough at a time.

About This Opportunity

Freenome is looking for an experienced infrastructure engineer to help build a cloud-native machine learning platform for the world’s largest multi-analyte cancer genomics dataset.

As an engineering-forward biotech company, we apply modern engineering practices to build reliable, maintainable, scalable, and secure production systems for our clinical lab and Computational and Molecular Research Scientists.

Our infrastructure team is a small group where you will help set the culture and build the systems that allow us to move fast without breaking things. This is an opportunity to do meaningful engineering work that will directly save lives.

The role reports to Director, Cloud Infrastructure.

What You’ll Do

Execution Excellence:

• Provide direct, strategic and tactical leadership to your department
• Provide leadership in developing new strategies, methodologies, and solutions to improve execution towards department- and company-level objectives
• Partner with our QA Department to ensure the highest level of regulatory compliance with recognized quality best practice
• Translate business segment strategy into cross-functional plans and guide plan execution
• Accountable for the performance and results of your department (Monitoring performance and initiating action to strengthen results)
• Proactively communicate cross-functionally with key stakeholders to adapt as needed through reprioritization and alignment
• Ensure budgets, resourcing and timelines meet company requirements
• Empowers department to take calculated risks and make mistakes as a team but collectively learn from these experiences, ensuring institutional knowledge is retained and applied in the future
• Comfortable navigating ambiguity, using trial and error to thoughtfully iterate towards the best solution balancing time and resource constraints
• Anticipate factors that could cause issues that have departmental or cross-functional impact and formulates preventive strategies

Communication And Collaboration

• Proactively requests feedback from others and are open to continuous feedback
• Consistently delivers actionable and timely feedback to people at all levels in a way that strengthens relationships and enables functional initiatives to advance more quickly
• Provide consistent communications to key functional and cross-functional stakeholders on progress and updates
• Guides department in effective communication and collaboration, avoiding triangulation or churn and fostering direct communication
• Adapts communications to audience requirements to optimize understanding and results, adapting to diverse communication styles
• Build and maintain strong, healthy relationships with cross-functional peers
• Provide representation for your department to executive leadership through reporting, presentations and Quarterly Business Review type meetings

Culture

• Lead by example, integrate and reinforce our Values and Principles as much as possible
• Coaches and provides guidance to direct reports to foster our Values and Principles across departments
• Recognizes Values and Principles gaps in your department on an ongoing basis and implement solutions and creates opportunities to grow in those areas

Technical Leadership

• Lead complex infrastructure and platform initiatives from design through delivery, collaborating across engineering and business teams
• Mentor junior and mid-level engineers, providing architectural guidance, code reviews, and hands-on support
• Act as a technical lead, helping shape platform strategy for platform infrastructure and SRE
• Help drive team-wide alignment on engineering best practices and long-term architectural direction
• Influence prioritization and planning in partnership with TPMs and engineering managers
• Actively involved in recruitment, attracting and retaining top talent to build high performing teams
• Effectively cascades organizational strategy and contributes to the development of organizational procedures
• Gives direction and organizational clarity in roles and responsibilities to execute on department and company OKRs more effectively

Must Haves

• B.S. or M.S. in computer science, engineering, or related field, or equivalent experience

• 8+ years of experience designing, building, and supporting cloud infrastructure, including production environments

• Demonstrated expertise in:

• Operating managed Kubernetes clusters in production environments

• Designing and maintaining cloud networking, IAM, and policy-based access controls

• Architecting secure, compliant infrastructure (e.g., NIST 800-53, 800-171, CIS Benchmarks)

• Proficiency with infrastructure-as-code tools such as Terraform or Pulumi, including module design and CI/CD integration

• Experience implementing observability solutions (e.g., metrics, logs, tracing, alerting) to maintain system health and reliability

• Hands-on experience with cloud migration and greenfield cloud architecture, including setting up secure cloud tenants and core infrastructure from the ground up

• Software design and development expertise, especially in Python

• Deep understanding of Linux internals and distributed systems troubleshooting

• Proven ability to support and scale production workloads on cloud platforms (AWS, Azure, or GCP)

• Excellent communication and cross-functional collaboration skills

Nice To Haves

• Experience in biotechnology, bioinformatics, regulated software, or similar field
• Monitoring, alerting, logging, and tracing tools, such as Prometheus, fluentd, or Jaeger
• Data pipelines, such as Kafka, Spark, Airflow, Argo, Beam, or Flink
• Experience in a startup environment
• Experience with software in a regulated environment
• Exposure to big data, especially biological and clinical data
• Experience with Microsoft Azure

Benefits And Additional Information

The US target range of our base salary for new hires is $188,275 - $288,500. You will also be eligible to receive pre-IPO equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.

Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

_Applicants have rights under Federal Employment Laws.

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• Family & Medical Leave Act (FMLA)
• Equal Employment Opportunity (EEO)
• Employee Polygraph Protection Act (EPPA)